Ching-Jen Wang
Kaohsiung Chang Gung Memorial Hospital, Taiwan
Title: Extracorporeal shockwave therapy for Osteoporotic Osteoarthritis of the Knee in Rats. An experiment in animals
Biography
Biography: Ching-Jen Wang
Abstract
The purpose of this study was to investigate the effectiveness of ESWT in osteoporotic osteoarthritis of the knee in rats. Sixty-four female S-D rats were divided into four groups. The control group received sham ovariectomy (OVX) and sham anterior cruciate transection (ACLT) and medial meniscectomy (MM). The osteoarthritis (OA) group received ACLT and MM, but no OVX. The osteoporosis (OP) group underwent bilateral OVX, but no ACLT and MM. The OA + OP group received bilateral OVX, ACLT and MM. One half of animals also received ESWT. The evaluations included the areas of gross pathology, bone mineral density (BMD), micro-CT scan, bone strength test, histopathological examination and immunohistochemical analysis. Group OA + OP showed larger areas of arthritic changes than groups OA and OP as compared to sham group. BMD and bone strength significantly decreased in groups OA, OP and OA+OP versus sham group, and ESWT significantly improved the changes. In micro-CT scan, subchondral plate thickness significantly decreased and bone porosity increased in groups OA, OP and OA+OP, and ESWT significantly improved the changes. .Mankin and Safranin O scores significantly increased in groups OA and OA+OP, relative to sham group, and ESWT significantly improved the changes,. DKK-1 significantly increased, and VEGF, PCNA and BMP-2 decreased in groups OA, OP and OA+OP relative to sham group, and ESWT significantly reversed the changes. This study showed that osteoporosis increased the severity of osteoarthritis of the knee. ESWT was shown effective to ameliorate osteoporotic osteoarthritis of the knee.