Luthfi Dharmawan
Padjadjaran University
Title: Decreased levels of serum chondroitin sulfate and pain numeric rating scale in patients with knee osteoarthritis after isotonic quadriceps strengthening exercise
Biography
Biography: Luthfi Dharmawan
Abstract
Background: Osteoarthritis (OA) is degenerative joint disease that is characterized by loss of cartilage. Chondroitin sulfate (CS) is an important structural component of cartilage. It is responsible for pressure resistance. CS can slow the progression of cartilage destruction and may help to regenerate the joint structure, leading to reduce pain of the affected joint. CS synthesis stimulated by mechanical forces. The mechanical force recommended for knee OA patients is an isotonic strengthening exercise of quadriceps muscles. Objective: To analyze the prevalence ratio between serum CS level and pain level after quadriceps isotonic strengthening exercise. Method: This study recruited 36 participants with Knee OA grade 2 and 3. The participants’ assessed for pain and their blood was taken before and after intervention. Participants practiced quadriceps isotonic strengthening exercise 3 times a week for 8 weeks. Results: The serum CS level and pain level shows decrease after intervention. The prevalence ratio between CS level and pain level is 1,548 (95% CI, 0,765–3,131) but statistically not significant. Conclusion: CS is synthesized by chondrocyte to stimulate an anabolic process of the cartilage metabolism and can stimulate an anti-inflammatory action. Even though statistically not significant, the prevalence ratio showed that serum level CS can influence the pain level of the patients. Based on the result, isotonic quadriceps strengthening exercise have a positively effect to the joint in patients with OA.